Thomas G. Beach, MD, PhD
Brain and Body Donation Program, Banner Sun Health Research Institute;
Head and Senior Scientist
Civin Laboratory for Neuropathology, Banner Sun Heath Research Institute
Thomas Beach is Head and Senior Scientist at the Civin Laboratory for Neuropathology, and Director of the Brain and Body Donation Program, both of which are located at Sun Health Research Institute in Sun City, Arizona. Dr. Beach has degrees in Biology (BS), Neuroscience (PhD) and Medicine (MD) from the University of British Columbia (UBC) in Vancouver, Canada.
Beach was trained in anatomic pathology and neuropathology at St. Louis University School of Medicine and at UBC. Prior to moving to Sun Health Research Institute in 1997, he was Assistant Professor in the Department of Pathology and Laboratory Medicine at UBC and staff Neuropathologist at Vancouver Hospital and Health Sciences Center and British Columbia’s Children’s Hospital.
Behavioral Neuroscience Program Professor
ASU School of Life Sciences
For over two decades Dr. Bimonte-Nelson has been conducting preclinical evaluations of multiple domains of cognitive function as related to aging, with a special focus on transitional and surgical menopause, and exogenous and endogenous hormone exposures across the lifespan. She has published over 70 peer reviewed manuscripts evaluating hormone effects on the brain and behavior from early development until old age, with her earlier work showing that female brain organization is actively feminized by estrogens, and that estrogen exposures across the lifespan impact the female phenotype. She has expertise in behavioral measurements and related neurobiological assays, especially as associated with aging and hormone milieu.
Psychology, Associate Professor
College of Liberal Arts and Sciences
Dr. Brewer’s interests include behavioral and electrophysiological recording of memory processes, prospective memory, source memory, recognition memory, individual differences in working memory, and emotional effects on memory. Additionally, he is interested in statistical models of memory and other statistical applications within psychology.
Paul Coleman, PhD
ASU-Banner Neurodegenerative Disease Research Center
Paul Coleman attended elementary, middle and high school at Friends Seminary in New York and then obtained an A.B. degree magna cum laude from Tufts. He next earned a Ph.D. in physiological psychology from the University of Rochester. After military service at the Army Medical Research Laboratory, Ft. Knox, KY, he completed a fellowship at Johns Hopkins School of Medicine. He spent several decades as a Full Professor at the University of Rochester School of Medicine during which time he was Director of the University of Rochester Medical Center Alzheimer’s Disease Center and Director of an NIH Training Program in Neurobiology of Aging. During this time, he also spent time at Cold Spring Harbor Laboratory. While at the University of Rochester he trained a number of students who are now Professors throughout the United States and Europe. In 2007 he moved his laboratory to the Banner Sun Health Research Institute. In 2015 he moved his laboratory to the Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University.
Ever since Dr. Coleman's first publication on Alzheimer's disease that indicated continuing neuronal plasticity in the aging human brain and loss of this plasticity in Alzheimer's disease (Science, 1979) his work has focused on differentiating changes in the brain in Alzheimer's disease from changes related to normal, non-demented ageing. His initial studies in this area were based on quantitative Golgi studies of dendritic extent in human and rodent brains. Feeling a need to be able to competently expand into studies using molecular biology, he spent much of two summers at Cold Spring Harbor Laboratories learning molecular biology and molecular biology methods. One of these summers resulted in the first publication (with Jim Eberwine in PNAS) of a method of profiling gene expression in single identified neurons. Most recently, Dr. Coleman’s work has expanded into the realm of epigenetics. This work is successfully demonstrating that reduced transport of epigenetic molecules from the cytoplasm into the cell nucleus is an early key event in the cellular pathology of Alzheimer's disease. This inability of epigenetic molecules to translocate to the nucleus, where they should be, has consequences for chromatin structure and consequently, the massive changes in gene expression seen in the AD brain. In addition, the aberrant cytoplasmic localization of epigenetic molecules leads to interactions with transport mechanisms in axons and dendrites, to interactions with mitochondria and to other interactions leading to the pathophysiology of Alzheimer's disease. Dr. Coleman has received a number of awards for his work, including a Leadership and Excellence in Alzheimer’s Disease Award from the National Institutes of Health (one of 12 ever awarded) and a Pioneer Award from the National Alzheimer’s Association.
Valentin Dinu, PhD
Associate Faculty, Biodesign Virginia G. Piper Center for Personalized Diagnostics
Associate Professor, Department of Biomedical Informatics
Valentin Dinu's research interests are the assessment, improvement, and development of computational approaches, software applications and databases that will facilitate the management, integration and analysis of diverse sources of biomedical information. Some of Valentin Dinu's teaching and research areas include 1) the use of biological domain knowledge to supplement statistical analysis and data mining methods to identify genes and pathways associated with disease, and 2) the exploration of database modeling approaches for managing large and heterogeneous data sets from both clinical and biosciences domains. Application domains include next generation sequencing (NGS), genome wide association studies (GWAS), and immunosignature protein arrays.
Mike Malek-Ahmadi, PhD, GStat
Bioinformatics Research Analyst
Banner Alzheimer's Institute
Dr. Malek-Ahmadi earned a BS in Psychology from the University of Arizona, a MS in Epidemiology from the University of South Florida, and a PhD in Psychology from the University of Westminster. He has worked in the field of Alzheimer’s disease research since 2003 and is an author on over 50 peer-reviewed journal articles in the areas of Alzheimer’s disease, mild cognitive impairment, and normal aging. Dr. Malek-Ahmadi’s current work at the Banner Alzheimer’s Institute involves the analysis of clinical, neuropsychological, and neuropathological data used toward identifying and characterizing pre-clinical Alzheimer’s disease.
ASU School of Life Sciences
Jason Newbern's research is centered on developmental neuroscience. His laboratory studies the biochemical mechanisms that direct the formation of the brain and spinal cord. He uses genetic, cellular, and molecular techniques to investigate the development of neurons and glia in the nervous system.
Kathy O’Connor, MS
Outreach Program Manager
Banner Sun Health Research Institute
Kathy O’Connor manages several programs including the Longevity Project, Learning from our Elders research project and Community Outreach for the Center for Healthy Aging at Banner Sun Health Research Institute in Sun City, Arizona.
Brain and Body Donation Program
Banner Sun Health Research Institute
In 2000 Dr. Serrano graduated with honors from the University of Puerto Rico, Cayey Campus, and worked for a year in a biochemistry laboratory at the University of Florida. In 2006 she completed her doctoral degree in Anatomy at the University of Puerto Rico, Medical Science Campus, where she developed scientific skills, not only technical but also analytical. While pursuing her doctoral degree, she received the Minority in Neuroscience Fellowship from the Society of Neuroscience and had the honor to do an Internship at the Marine Biological Laboratory at Woods Whole, MA. In 2007 she started a postdoctoral appointment at Emory University’s School of Medicine and received a National Research Service Award Training Grant (F32-NINDS). After three years of postdoctoral training, she joined the Brain and Body Donation program at Banner Sun Health Research, Sun City, Arizona. Her work allows her to contribute to brain and biospecimen research that pursues the understanding of neurological disorders around the world.
Dr. Serrano’s most recent research contributions are in neurodegeneration of aging in humans and gender differences. Her most recent publication suggests that, when affected by Alzheimer’s Disease, females progress more often to severe cognitive dysfunction, due to more severe neurofibrillary degeneration and greater loss of brain parenchyma. Other relevant work involved the search for a peripheral biopsy for Parkinson Disease and a feasibility study of frontal cortex needle core biopsy for detection of characteristic proteinopathies of neurodegenerative diseases.
Sarah Stabenfeldt, PhD
Assistant Professor, Biological and Health Systems Engineering
Associate Professor, School of Life Sciences
Sarah Stabenfeldt received her bachelor's degree in biomedical engineering from Saint Louis University and her doctorate in bioengineering from Georgia Institute of Technology. She was awarded a National Institutes of Health (NIH) NRSA pre-doctoral fellowship for her doctoral thesis research on developing neural tissue engineering therapies for traumatic brain injury. As a NIH postdoctoral fellow at Emory University School of Medicine and Georgia Tech, she investigated fibrin-derived peptide-protein binding interactions, designing fibrin-based wound healing therapeutics. She joined Arizona State University’s School of Biological and Health Systems Engineering as an assistant professor in 2011 and leads her research team in developing regenerative medicine strategies for acute neural injury. Since joining ASU, Stabenfeldt has been awarded the Arizona Biomedical Research Consortium Early Stage Investigator Award, the NIH Director’s New Innovator Award, and a National Science Foundation (NSF) CAREER Award.